Naomi Osaka bundled out by Katerina Siniakova

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Having won the U.S. and Australian Opens, the 21-year-old Japanese is on a mission to become the first woman to win three Grand Slams on the trot since her idol Serena Williams in 2015.

Former world number one Serena Williams was knocked out of the French Open after she was defeated by Sofia Kenin 6-2 7-5 in the third round on Saturday.

The US Open and Australian Open champion had to come from behind to beat Anna Karolina Schmiedlova and Victoria Azarenka in her opening two matches and she could not do it a third time.

The 20-year-old Kenin, who was born in Russian Federation, has now won 11 of her last 13 against American foes on tour. She gets angry at herself but then it's "OK, next point, it's all good".

Barty made it as far as the fourth round only once in her first 17 Grand Slam appearances; she's made it to the quarterfinals at each of the past two.

Kenin performed brilliantly to reach the last 16 of a major for the first time in her career, meaning Wimbledon is Williams' next chance of getting the record-equalling piece of silverware.

In Tuesday's quarterfinals on the other half of the bracket, 2017 U.S. Open champion Sloane Stephens meets No. 26 Johanna Konta of Britain, and No. 31 Petra Martic of Croatia faces 19-year-old Marketa Vondrousova of the Czech Republic.

The 23-year-old, who has risen to eighth in the world on the back of a sparkling recent run of form, breezed past German Andrea Petkovic 6-3 6-1 in the third round at Roland Garros.

"It's my first time this week playing on this attractive court and I just wanted to come out here and enjoy it", said Barty.

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Japanese world No. 1 Naomi Osaka, victor of the past two Grand Slam tennis events, also fell victim to an upset, losing to Czech Katerina Siniakova 6-4, 6-2.

If Osaka's form had been hit and miss in the opener, it deteriorated in set two, with her backhand particularly erratic.

"So I have some time on my hands, so maybe I'll jump in and get a wildcard on one of these grass court events and see what happens".

Ashleigh Barty next plays Madison Keys, the American 14th seed. "All I know is, she was not ready and it was obvious, I think".

"I think obviously there's a little bit more talk around and a little bit more attention", she said after fending off American Sofia Kenin 6-3 3-6 6-0.

"It's just been a really gruelling season".

"At least I can start trying to put the time in now".

"I would love to forget that match at the French Open", said Barty. In men's action, where all top 10 seeds reached the fourth round, No. 1 Novak Djokovic plays 45th-ranked Jan-Lennard Struff of Germany.

"I just feel like there has been a weight on me", Osaka told reporters after the Czech ended a 16-match win streak in the grand slams.

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